Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population.
Article
in English
| IMSEAR
| ID: sea-135597
ABSTRACT
Background & objective:
Renin-angiotensin aldosterone system (RAAS) plays an important role in the regulation of blood pressure. Aldosterone, synthesized by aldosterone synthase in the adrenal cortex is encoded by the CYP11B2 gene. In this case-control study we examined the association between CYP11B2 C-344T polymorphism and essential hypertension in south Indian Tamil population.Methods:
The study was conducted in 406 hypertensive cases and 424 healthy controls from Tamil population. Genotyping was performed by PCR-restriction fragment length polymorphism method. Statistical analysis was performed by logistic regression analysis.Results:
The 344TT homozygous variant genotype (OR-1.8; 95% CI 1.1-2.8; P=0.02) and T allele (P=0.007) were found to be significantly associated with hypertension. In gender based analysis, the risk was significantly higher in male hypertensives (OR-1.8; 95% CI 1.0-3.6, P=0.05) but not in female subjects. Interpretation &conclusion:
A significant association between CYP11B2 gene polymorphism and essential hypertension was observed and the risk was confined to male subjects in south Indian Tamil population.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Renin-Angiotensin System
/
Female
/
Humans
/
Male
/
Ethnicity
/
Logistic Models
/
Odds Ratio
/
DNA Primers
/
Cytochrome P-450 CYP11B2
/
Adult
Type of study:
Etiology study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Year:
2010
Type:
Article
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