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Role of connexin 26 (GJB2) & mitochondrial small ribosomal RNA (mt 12S rRNA) genes in sporadic & aminoglycoside-induced non syndromic hearing impairment.
Article in English | IMSEAR | ID: sea-135907
ABSTRACT
Non syndromic hearing impairment is a common sensory disorder, which affects one in 600 newborns. Though more than 50 nuclear genes are involved in causing non syndromic hearing impairment, mutations in the connexin 26 (GJB2) gene explain a high proportion of congenital deafness in several populations worldwide. The diversity of genes and genetic loci implicated in hearing loss defines the complexity of the genetic basis of hearing. This review focuses on the role of connexin 26 and mitochondrial 12S rRNA genes in hearing which will be helpful for better understanding of genes in sporadic and aminoglycosideinduced non syndromic hearing impairment.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / RNA, Ribosomal / Connexins / Deafness / Aminoglycosides / Hearing / Hearing Loss / Mitochondria / Mutation Language: English Year: 2009 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / RNA, Ribosomal / Connexins / Deafness / Aminoglycosides / Hearing / Hearing Loss / Mitochondria / Mutation Language: English Year: 2009 Type: Article