Utility of QuantiFERON TB gold test in a south Indian patient population of ocular inflammation.
Indian J Ophthalmol
;
2009 Nov; 57(6): 427-430
Article
in English
| IMSEAR
| ID: sea-135993
ABSTRACT
Aim:
To study the utility of interferon-γ release assays (QuantiFERON TB gold test) in a south Indian patient population of intraocular inflammation.Design:
Evaluation of a diagnostic test- a pilot study from January 2007 to October 2008. Materials andMethods:
QuantiFERON TB gold test was performed on the following groups of patients following an informed consent. Group A included healthy volunteers without any exposure to tuberculosis (TB) or past history of TB (n=22). Group B included patients with active systemic TB diagnosed by the demonstration of acid-fast bacilli or by the histopathology finding of caseation with granuloma formation from the sputum, lymph node, skin or intestinal biopsies (n=26). Group C included patients with uveitis of known etiologies other than intraocular TB without any history of exposure to active TB (n=21). Group D included patients with a diagnosis of presumed intraocular TB, who responded to antitubercular therapy by decreased or no recurrences following treatment and with a minimum of nine months follow-up following initiation of antitubercular therapy (n=39).Results:
The sensitivity and specificity of the QuantiFERON TB gold test to pick up active systemic TB was 58% and 77% respectively. The sensitivity and specificity of the QuantiFERON TB gold test to pickup intraocular TB was 82% and 76% respectively.Conclusions:
QuantiFERON TB gold test alone may not be specific for intraocular TB. The significance of this test in a case scenario needs to be interpreted with clinical presentation and other evidences for intraocular TB.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reagent Kits, Diagnostic
/
Humans
/
Pilot Projects
/
Tuberculosis, Ocular
/
Incidence
/
Predictive Value of Tests
/
Retrospective Studies
/
Sensitivity and Specificity
/
Interferon-gamma
/
Diagnosis, Differential
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Ophthalmol
Year:
2009
Type:
Article
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