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Comparative role of intravitreal ranibizumab versus bevacizumab in choroidal neovascular membrane in age-related macular degeneration.
Indian J Ophthalmol ; 2011 May; 59(3): 191-196
Article in English | IMSEAR | ID: sea-136168
ABSTRACT
Context Ranibizumab and bevacizumab are used widely for treating patients with choroidal neovascular membrane (CNVM) secondary to age-related macular degeneration (AMD).

Aims:

To determine and compare the efficacy and safety of intravitreal ranibizumab and bevacizumab in treatment of CNVM due to AMD. Settings and

Design:

Prospective comparative case series carried out in an eye institute and eye department of a hospital in Kolkata, India. Materials and

Methods:

One hundred and four eyes with CNVM due to AMD were randomized into two groups. Group A (n=54; 24 occult) received monthly intravitreal ranibizumab injections (0.5 mg in 0.05 ml) and Group B (n=50; 22 occult) received monthly bevacizumab injections (1.25 mg in 0.05 ml) for 3 consecutive months and then as per study criteria. Data analysis done using SPSS software. P-value of <0.05 was considered statistically significant.

Results:

The mean best corrected visual acuity (BCVA) in the ranibizumab group increased from 58.19 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at baseline to 64 ETDRS letters at month 3 (P<0.001). In bevacizumab group mean BCVA increased from 56.80 to 61.72 ETDRS letters at month 3 (P<0.001). At the end of 18 months, there was no statistically significant difference between groups A and B with respect to change in BCVA (P=0.563) or central macular thickness (CMT; P=0.281), as measured by optical coherence tomography (Stratus OCT 3000). No significant sight-threatening complications developed.

Conclusions:

Ranibizumab and bevacizumab are equally safe and efficacious in treating CNVM due to AMD.
Subject(s)

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Humans / Male / Prospective Studies / Treatment Outcome / Choroidal Neovascularization / Angiogenesis Inhibitors / Intravitreal Injections / Antibodies, Monoclonal, Humanized / Macular Degeneration Type of study: Controlled clinical trial / Observational study Language: English Journal: Indian J Ophthalmol Year: 2011 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Humans / Male / Prospective Studies / Treatment Outcome / Choroidal Neovascularization / Angiogenesis Inhibitors / Intravitreal Injections / Antibodies, Monoclonal, Humanized / Macular Degeneration Type of study: Controlled clinical trial / Observational study Language: English Journal: Indian J Ophthalmol Year: 2011 Type: Article