Platelet aggregation and lipid profile in offsprings of young ischemics.

ABSTRACT

OBJECTIVE: To study the platelet aggregation and lipid profile in offsprings of young ischemic parents. DESIGN: Cross sectional. SETTING: Hospital based. METHODS: 40 adults under 45 years of age with proven CHD and their 50 offsprings comprised the study group. In the control group, 40 age matched adults with normal maximal treadmill test and their 50 off springs were included. All were screened for lipid profile and platelet aggregation. RESULTS: Platelet aggregation was significantly elevated in adults with CHD (44.0 +/- 15.5%) compared to controls (32.22 +/- 9.1%). Children of CHD adults also had significantly elevated aggregation (34.9 +/- 12.5%) compared to control offsprings (27.8 +/- 9.9%). Adult CHD subjects had significantly elevated serum cholesterol, LDL-cholesterol (LDL-C) and atherogenic index compared to control adults. The children in both groups had similar lipid profiles. CONCLUSION: Platelet aggregation is enhanced in offsprings of young ischemics. The potential of this index as a marker for early development of CHD needs to be explored.