Serum levels of malondialdehyde in type 2 diabetes mellitus Thai subjects.

ABSTRACT

Objective: To investigate the serum MDA levels, as a biomarker of lipid peroxidation in T2D patients and the association with the other conventional cardiovascular risk factors (Glu, TC, TG, HDL-C, LDL-C, waist circumference, and BP). Methods: Serum levels of malondialdehyde (MDA) are the most commonly used markers of this process measured as thiobabituric acid reaction substances (TBARS). The MDA-TBA adduct has a colorimetric measurement of 532 nm. A total of 50 T2D patients and a group of 40 healthy controls participated in this study. Results: The MDA concentrations of the 40 healthy controls ranged from 0.699 to 2.684 mol/l. The serum levels of MDA concentration in type 2 diabetes patients were significantly elevated (P<0.001) compared with the healthy controls. MDA levels were significantly correlated (P<0.05) with conventional cardiovascular risk factors (age, Glu, LDL-C, HDL-C, TC, TG, UA, waist circumference, and blood pressure). Conclusion: Serum levels of MDA were significantly increased in T2D patients. It may be a good marker for lipid peroxidation or an oxidative stress event that is implicated in various pathological conditions.