Estimated creatinine clearance and microalbumin levels for early prediction of nephropathy in adults with diabetes mellitus.

ABSTRACT

Objective: To evaluate the association of microalbumin, estimated creatinine clearance (eCrCl), and the other variables in type 2 diabetes (T2D) patients for the prediction of early nephropathy. Methods: Fasting plasma glucose, serum BUN, total cholesterol (TC), triglyceride (TG), HDL-C, serum creatinine, and urine microalbumin were measured with a Hitachi 912 autoanalyzer as microalbumin/gram of creatinine (g CT). The Cockroft-Gault formula was used to calculate the eCrCl and the eCrCl was subdivided as defined by the Kidney Disease Outcome Quality Initiative. Results: In a total of 93 patients, these were 50 patients having T2D and 43 control patients having non-diabetes (NDM). The T2D patients were significantly higher in systolic, diastolic blood pressure, serum creatinine, and urine microalbumin than the NDM patients (P<0.05), and the T2D patients were significantly lower in eCrCl than the NDM patients (P<0.001). The eCrCl was significantly reverse correlated with the duration of abnormal glucose metabolism and age (P<0.05). Conclusion: The eCrCl is important in T2D patients. A decrease in eCrCl with or without an increase in microalbumin excretion may be the universal indication of the presence of diabetic glomerular pathology.