Effect cisapride on gastric emptying and dyspeptic symptoms in children with non-ulcer dyspepsia.

ABSTRACT

The aim of our study was to determine the effect of Cisapride on gastric emptying and dyspeptic symptoms in 10 non-ulcer dyspepsia (NUD) children with delayed gastric emptying during and after stopping treatment. Five boys and five girls aged 5-11 years underwent upper endoscopy which showed normal appearing mucosa and histology. Solid gastric emptying was measured by scintigraphy before and after an eight-week course of oral Cisapride. The dose of cisapride was 0.2 mg/kg/dose (maximum 5 mg) three times before meals for eight weeks and then gradually decreased and discontinued when the symptoms improved. Symptoms were show to be 87.4+3.4 percent and 82.9 (4.5 percent at 60 minutes and 90 minutes, respectively. After eight-weeks of treatment, repeated gastric emptying studies were shown to be 69.1+10.6 percent and 56.7+14.1 percent respectively. This was statistically significant (P=0.001, 0.0001). In all 10 children the symptoms improved after eight-weeks of treatment. Seven children were followed up after stopping cisapride for 3 to 17.5 months. The overall response were excellent in four patients, moderate in two Cisapride is effective in improving dyspeptic symptoms and gastric emptying in children with NUD.