Dissolution profile of three brands carbamazepine tablets.

Three brands of carbamazepine tablets available in Thailand were assessed for their pharmaceutical properties according to the requirement of pharmacopoeia. The present study demonstrated that the dissolution profile of CBZ tablets varied markedly to the hardness of the tablet. All brands of CBZ tablet tested fulfill most of the pharmacopoeial requirements, (e.g. weight variation, content uniformity, disintegration tie, etc.), except the dissolution and the friability limit. The present results indicate the problem of dissolution of CBZ tablet. However, Thai FDA has not yet required the dissolution limit for CBZ tablet. The present study, therefore, provide the evidence for addition of CBZ tablet to the list of drugs that are subjected to the dissolution testing.