Subchronic toxicity of murdannia ioriformos.

ABSTRACT

One hundred and twenty male and female rats, 150-200 gm of body weight, were randomly divided into 4 groups and acclimatized to controlled conditions for 2 weeks. One served as a control group and the others were orally given fresh juice “Yaa Bei-jing” every day for 3 months. The dose given were 700, 1750, 3500 mg of plant per 250 gm of body weight were equal to 1, 2.5, 5 times of therapeutic dose used in man multiplied by 7. Body weight was observed every week to show their normal growths. Ten rats from each group were sacrificed every month to determine blood chemistry, CBC, pathological findings of the lungs, kidneys, livers, spleens, testes or ovaries. Up to 4, 8 and 12 weeks of experimental period, no abnormal results occurred.