Antibody responses to two different yeast-derived hepatitis B vaccines.

ABSTRACT

Comparative study of antibody responses and adverse reactions after two different yeast derived hepatitis B vaccine administrations was performed. Subjects were 96 medical students who had seronegative for HBV markers. The first group of 47 students received H-B-Vax II® vaccine (MSD) 10 µg and the second group (49 students) received Engerix-B® vaccine (SKF-RIT) 20 µg. the vaccination schedule was two doses one month apart and a booster dose at sixth month. Antibody responses were measured at 1 month after each injection. The result showed that, seroconversion rate after booster dose was 100% in both groups. Anti-HBs titers after first and second doses showed no significant difference among two groups, but after booster dose the anti-HBs geometric mean titer was 3,070 mIU/ml in the first group and 6,634 mIU/ml in the second group, which showed statistical significance. Minor adverse reactions such as local pain, inflammation, itching, and malaise were found.