Prenatal diagnosis of genetic disorder by aminotic fluid cell culture.

ABSTRACT

Eighty one samples of prenatal diagnosis for genetic disorder by amniotic fluid cell culture were studied. The study period was from January 1984 to 28 February 1987. Amniotic fluid cell culture were analyzed from 18 women who had previous child with Down’s Syndrome, a cases in which the family and congenital anomalies, 53 cased of advanced maternal age (> 35 years old) and 2 cases of miscellaneous (habitual abortion, X-ray) 2 cases. The success rate of the culture was 96.2 per cent. This study found the abnormality of amniotic Fluid cell culture in 3 cases. Two cases were Down’s Syndrome and one case was Klinefelter’s Syndrome. These three cases were proved by chromosome analysis of skin and lung culture.