Double-blind trial on ornidazole and tinidazole in a single low dosage regimen in amoebic liver abscess.

ABSTRACT

A double-blind trial on ornidazole and tinidazole was studied with 46 patients suffering from the amoebic liver abscess. Thirty eight patients were male and eight patients were female. Group I consisted of 21 males and 4 females and single dose of ornidazole 2,000 mg. was given orally. Group II consisted of 17 males and 4 females and the same dose of tinidazloe was given orally. The treatment also included liver aspiration every other day from the big abscess and every 3 days from the small abscess. The results of treatment were successful and there was no significant difference between the two groups, except one case treated by tinidazole had a recurrence of the abscess after follow up 4 months later. The cure rate of group I was 100 percent and of group II 95.45 percent. The observed side effects were loss of consciousness for a few minutes in one case from group I and dizziness and vomiting in one case from group II.