Effect of deferiprone on urinary zinc excretion in multiply transfused children with thalassemia major.
Indian Pediatr
;
2005 Feb; 42(2): 150-4
Article
in English
| IMSEAR
| ID: sea-13857
ABSTRACT
A prospective multi-centric study was conducted to determine if iron-chelating agent deferiprone also chelates zinc. Twenty four-hour urinary zinc levels were compared in multiply transfused children with thalassemia major not receiving any chelation therapy (Group A, n = 28), those receiving deferiprone (Group B, n = 30) and age and sex-matched controls of subjects in Group B (Group C, n = 29) by a colorimetric method. The 24-hour mean urinary excretion of zinc was significantly higher in Group B than in the other two groups indicating that deferiprone chelates zinc.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyridones
/
Time Factors
/
Zinc
/
Blood Transfusion
/
Female
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Iron Chelating Agents
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Indian Pediatr
Year:
2005
Type:
Article
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