Depleted immunoglobulin heavy chain binding protein (BiP) expands the endoplasmic reticulum and the golgi apparatus in dengue virus-infected cells.
Article
in English
| IMSEAR
| ID: sea-138593
ABSTRACT
Objective:
To test whether depleted expression of immunoglobulin heavy chain binding protein (BiP), which is an endoplasmic reticulum (ER) chaperone, in dengue virus (DENV)-infected cells, affected integrities of the ER and the Golgi apparatus of the host cells.Methods:
Either siRNA against BiP- or control siRNA-transfected cells was infected with DENV and subjected to electron microscopic evaluation.Results:
Depleted expression of BiP affected integrities of the ER and the Golgi apparatus in DENV-infected cells.Conclusion:
Integrities of the ER and the Golgi apparatus maintained by BiP in the host cells is necessary for DENV production.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2012
Type:
Article
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