A study of high-sensitivity c-reactive protein in bronchial asthma.
Article
in English
| IMSEAR
| ID: sea-138749
ABSTRACT
Background. Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. Objective. To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. Methods. The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. Results. There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. Conclusions. The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Asthma
/
Spirometry
/
Severity of Illness Index
/
Female
/
Humans
/
Male
/
C-Reactive Protein
/
Biomarkers
/
Forced Expiratory Volume
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2009
Type:
Article
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