Central retinal vein occlusion in a patient after being commenced on sildenafil citrate for pulmonary arterial hypertension.

Pinto, Lancelot M; Morekar, Sunil; Mahashur, Ashok A

Pinto, Lancelot M; Morekar, Sunil; Mahashur, Ashok A.

Article in English | IMSEAR | ID: sea-138756

ABSTRACT

ABSTRACT

A 75-year-old female was commenced on sildenafil for the treatment of pulmonary arterial hypertension (PAH) secondary to chronic obstructive pulmonary disease (COPD). She reported blurring of vision within 72 hours after starting treatment and was found to have a central retinal vein occlusion (CRVO). Such an occurrence is the second case reported to date, and we review the possible mechanisms and literature on the subject.

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3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors; Aged; Diagnosis, Differential; Female; Humans; Hypertension, Pulmonary/drug therapy; Phosphodiesterase Inhibitors/adverse effects; Phosphodiesterase Inhibitors/therapeutic use; Piperazines/adverse effects; Piperazines/therapeutic use; Purines/adverse effects; Purines/therapeutic use; Retinal Vein Occlusion/chemically induced; Retinal Vein Occlusion/diagnosis; Sulfones/adverse effects; Sulfones/therapeutic use

Sildenafil; Central retinal vein occlusion

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phosphodiesterase Inhibitors / Piperazines / Purines / Sulfones / Retinal Vein Occlusion / Aged / Female / Humans / 3',5'-Cyclic-GMP Phosphodiesterases / Diagnosis, Differential Type of study: Diagnostic study Language: English Year: 2009 Type: Article

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