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Interpreting a genetic case-control finding: What can be said, what cannot be said and implications in Indian populations.
Indian J Hum Genet ; 2007 Jan; 13(1): 1-4
Article in English | IMSEAR | ID: sea-138816
ABSTRACT
Identification of genetic variants responsible for complex disorders using association mapping is an active area of research. There are two broad classes of association methodologies population-based case-control studies and family-based transmission analyses. While case-control analyses are more popular and in general, more powerful than family-based analyses, they suffer from some inherent limitations. Thus, it is of importance, to understand the implications of an association finding obtained from a case-control study design. This article discusses the relative advantages and disadvantages of the two classes of association analyses, particularly in the context of genetic diversity in Indian populations.

Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Indian J Hum Genet Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study / Prognostic study / Risk factors Language: English Journal: Indian J Hum Genet Year: 2007 Type: Article