Interpreting a genetic case-control finding: What can be said, what cannot be said and implications in Indian populations.
Indian J Hum Genet
;
2007 Jan; 13(1): 1-4
Article
in English
| IMSEAR
| ID: sea-138816
ABSTRACT
Identification of genetic variants responsible for complex disorders using association mapping is an active area of research. There are two broad classes of association methodologies population-based case-control studies and family-based transmission analyses. While case-control analyses are more popular and in general, more powerful than family-based analyses, they suffer from some inherent limitations. Thus, it is of importance, to understand the implications of an association finding obtained from a case-control study design. This article discusses the relative advantages and disadvantages of the two classes of association analyses, particularly in the context of genetic diversity in Indian populations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Indian J Hum Genet
Year:
2007
Type:
Article
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