Y-haplotypes and idiopathic male infertility in an Indian population.
Indian J Hum Genet
;
2009 Jan; 15(1): 19-22
Article
in English
| IMSEAR
| ID: sea-138865
ABSTRACT
Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Population
/
Y Chromosome
/
Haplotypes
/
Humans
/
Male
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
India
/
Infertility, Male
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Hum Genet
Year:
2009
Type:
Article
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