High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene.
Indian J Hum Genet
;
2009 May; 15(2): 49-53
Article
in English
| IMSEAR
| ID: sea-138870
ABSTRACT
In this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Introns
/
Family
/
Risk
/
Genetic Predisposition to Disease
/
Nitric Oxide Synthase Type III
/
Food Preferences
/
Genotype
Type of study:
Etiology study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Hum Genet
Year:
2009
Type:
Article
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