Risk factors associated with MDR-TB at the onset of therapy among new cases registered with the RNTCP in Mumbai, India.
Indian J Public Health
;
2011 Jan-Mar; 55(1): 14-21
Article
in English
| IMSEAR
| ID: sea-139316
ABSTRACT
Background:
Multidrug - resistant TB (MDR - TB) has emerged as a major threat to global TB control efforts in recent years. Facilities for its diagnosis and treatment are limited in many high - burden countries, including India. In hyper - endemic areas like Mumbai, screening for newly diagnosed cases at a higher risk of acquiring MDR - TB is necessary, for initiating appropriate and timely treatment, to prevent its further spread.Objective:
To assess risk factors associated with MDR - TB among Category I, new sputum smear-positive cases, at the onset of therapy. Materials andMethods:
The study applied an unmatched case - control design for 514 patients (106 cases with MDR - TB strains and 408 controls with non - MDR - TB strains). The patients were registered with the Revised National Tuberculosis Control Program (RNTCP) in four selected wards of Mumbai during April 2004 - January 2007. Data were collected through semi - structured interviews and drug susceptibility test results.Results:
Multivariate analysis indicated that infection with the Beijing strain (OR = 3.06; 95% C.I. = 1.12 - 8.38; P = 0.029) and female gender (OR = 1.68; 95% C.I. = 1.02 - 2.87; P = 0.042) were significant predictors of MDR-TB at the onset of therapy.Conclusion:
The study provides a starting point to further examine the usefulness of these risk factors as screening tools in identifying individuals with MDR-TB, in settings where diagnostic and treatment facilities for MDR-TB are limited.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Prognostic study
/
Qualitative research
/
Risk factors
Language:
English
Journal:
Indian J Public Health
Year:
2011
Type:
Article
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