Prevalence of methylenetetrahydrofolate reductase C677T polymorphism in eastern Uttar Pradesh.
Indian J Hum Genet
;
2012 Jan; 18(1): 43-46
Article
in English
| IMSEAR
| ID: sea-139441
ABSTRACT
AIM:
This study was aimed to evaluate the 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T mutation in eastern Uttar Pradesh population. MATERIALS ANDMETHODS:
Polymerase chain reaction (PCR) using specific primers followed by amplicon digestion by Hinf I restriction enzyme was used for MTHFR C677T polymorphism analysis. Total 250 subjects were analyzed.RESULTS:
The CC genotype was found in 192 subjects, followed by CT in 56 subjects and TT in 2 subject. Genotype frequencies of CC, CT and TT were 0.768, 0.224 and 0.008, respectively. The frequency of C allele was found to be 0.88 and that of T allele was 0.12.CONCLUSION:
It is evident from the results of the present study that the percentage of homozygous genotype (CC) is highest in the target population.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Aged
/
Humans
/
Polymerase Chain Reaction
/
Prevalence
/
Adolescent
/
Adult
/
5,10-Methylenetetrahydrofolate Reductase (FADH2)
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Homocysteine
Type of study:
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Hum Genet
Year:
2012
Type:
Article
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