Karyotypic findings in chronic myeloid leukemia cases undergoing treatment.
Indian J Hum Genet
;
2012 Jan; 18(1): 66-70
Article
in English
| IMSEAR
| ID: sea-139445
ABSTRACT
BACKGROUND:
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells. MATERIALS ANDMETHODS:
In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.RESULTS:
Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.CONCLUSION:
This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Piperazines
/
Pyrimidines
/
Philadelphia Chromosome
/
Female
/
Humans
/
Male
/
Hematopoietic Stem Cells
/
Leukemia, Myeloid, Chronic-Phase
/
Child
/
Hospitals
Type of study:
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Hum Genet
Year:
2012
Type:
Article
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