Inbreeding as a cause for deafness: Dadhkai study.

Razdan, Sushil; Raina, Sunil Kumar; Pandita, Kamal K; Razdan, Shiveta; Nanda, Renu; Kaul, Rajni; Dogra, Sandeep

Razdan, Sushil; Raina, Sunil Kumar; Pandita, Kamal K; Razdan, Shiveta; Nanda, Renu; Kaul, Rajni; Dogra, Sandeep.

Indian J Hum Genet ; 2012 Jan; 18(1): 71-74

Article in English | IMSEAR | ID: sea-139446

ABSTRACT

ABSTRACT

BACKGROUND:

We report on the higher prevalence of deaf-mutes from a village in Jammu and Kashmir State of India. MATERIALS AND

METHODS:

A cross-sectional study among 79 deaf mutes using pedigree analysis, audiometry, imaging and molecular analysis.

RESULTS:

A high rate of hereditary deafness with 79 individuals diagnosed to be suffering from non-syndrome deafness in a total population of 2452 individuals residing in the village.

INTERPRETATION:

Flourishing of intermarriages led to a population with high prevalence of deafness.

Subject(s)

Consanguinity; Deafness/epidemiology; Deafness/etiology; Deafness/genetics; Humans; India; Marriage/trends; Mutism/epidemiology; Mutism/etiology; Mutism/genetics; Rural Population

Dadhkai; deafness; inbreeding

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rural Population / Humans / Marriage / Consanguinity / Deafness / India / Mutism Type of study: Observational study / Risk factors Country/Region as subject: Asia Language: English Journal: Indian J Hum Genet Year: 2012 Type: Article

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