Recombination in human leukocyte antigen region in two Asian Indian families.
Indian J Hum Genet
;
2012 Jan; 18(1): 109-111
Article
in English
| IMSEAR
| ID: sea-139454
ABSTRACT
BACKGROUND:
Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles. SETTINGS ANDDESIGN:
A prospective study at a tertiary care centre.AIM:
To report two rare cases of crossing over in HLA region. MATERIALS ANDMETHODS:
Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.RESULTS:
In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.CONCLUSIONS:
Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Recombination, Genetic
/
Humans
/
Family
/
Asian People
/
Histocompatibility Antigens
/
HLA Antigens
/
India
/
Major Histocompatibility Complex
Type of study:
Observational study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Hum Genet
Year:
2012
Type:
Article
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