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Preoperative ephedrine counters hypotension with propofol anesthesia during valve surgery: A dose dependent study.
Ann Card Anaesth ; 2011 Jan; 14(1): 30-40
Article in English | IMSEAR | ID: sea-139559
ABSTRACT
The prophylactic use of small doses of ephedrine may counter the hypotension response to propofol anesthesia with minimal hemodynamic changes. One hundred-fifty patients scheduled for valve surgery were randomly assigned into five groups (n = 30 for each) to receive saline, 0.07, 0.1, or 0.15 mg/kg of ephedrine, or phenylephrine 1.5 μg/kg before induction of propofol-fentanyl anesthesia. After induction, patient receiving ephedrine had higher mean arterial pressure, systemic vascular resistance (SVRI), cardiac (CI), stroke volume (SVI), and left ventricular stroke work (LVSWI) indices. Patients received 0.15 mg/kg of ephedrine showed additional increased heart rate and frequent ischemic episodes (P < 0.001). However, those who received phenylephrine showed greater rise in SVRI, reduced CI, SVI, and LVSWI and more frequent ischemic episodes. We conclude that the prophylactic use of small doses of ephedrine (0.07−0.1 mg/kg) is safe and effective in the counteracting propofol-induced hypotension during anesthesia for valve surgery.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rheumatic Heart Disease / Female / Humans / Male / Logistic Models / Propofol / Double-Blind Method / Anesthetics, Intravenous / Adult / Dose-Response Relationship, Drug Type of study: Controlled clinical trial / Risk factors Language: English Journal: Ann Card Anaesth Year: 2011 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rheumatic Heart Disease / Female / Humans / Male / Logistic Models / Propofol / Double-Blind Method / Anesthetics, Intravenous / Adult / Dose-Response Relationship, Drug Type of study: Controlled clinical trial / Risk factors Language: English Journal: Ann Card Anaesth Year: 2011 Type: Article