The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting.
Ann Card Anaesth
;
2012 Jan; 15(1): 18-25
Article
in English
| IMSEAR
| ID: sea-139629
ABSTRACT
The clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stress, Psychological
/
Aged
/
Female
/
Humans
/
Male
/
Fentanyl
/
Double-Blind Method
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Coronary Artery Bypass, Off-Pump
/
Gamma-Aminobutyric Acid
/
Hemodynamics
Type of study:
Controlled clinical trial
Language:
English
Journal:
Ann Card Anaesth
Year:
2012
Type:
Article
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