Association between gingival crevicular fluid prostaglandin E 2 level and preterm low birth weight.
Article
in English
| IMSEAR
| ID: sea-140195
ABSTRACT
Background:
Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E 2 (PGE 2 ), may pose a threat to the fetal-placental unit and cause preterm delivery.Aim:
This study was conducted to estimate the PGE 2 levels in gingival crevicular fluid (GCF) and to explore the association between GCF-PGE 2 levels and preterm low birth weight (PLBW). Materials andMethods:
Twenty-two pregnant patients were selected for the study. GCF samples were collected from these patients before delivery and again at 1 month after delivery. PGE 2 level was estimated using a commercially available ELISA kit (Neogen™).Results:
The mean GCF-PGE 2 level was 5.8 ng/ml before parturition and 5.5 ng/ml after parturition, but the difference was not statistically significant. There was negative correlation between PGE 2 levels and gestational age at birth.Conclusion:
The study provides weak evidence that there is correlation between GCF-PGE 2 levels and birth outcome. Further clinical trials with large samples are required to confirm the association between GCF-PGE 2 levels and PLBW.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Birth Weight
/
Female
/
Humans
/
Infant, Low Birth Weight
/
Infant, Newborn
/
Pregnancy
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Pregnancy Outcome
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Dinoprostone
/
Oral Hygiene Index
/
Periodontal Index
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2012
Type:
Article
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