Comparison of seropositivity of human T lymphotropic virus type 1 in mycosis fungoides patients and normal volunteers: A case-control study and review of literature.
Indian J Dermatol Venereol Leprol
;
2009 Jul-Aug; 75(4): 363-367
Article
in English
| IMSEAR
| ID: sea-140384
ABSTRACT
Background:
There have been controversial reports about the possible association between mycosis fungoides (MF), its leukemic variant Sιzary syndrome (SS) and human T lymphotropic virus type 1 (HTLV-1) in different geographical regions.Aims:
The purpose of this study was to explore any association between MF and presence of HTLV-1 infection in Iran.Methods:
In a case-control setting, 150 clinically and histopathologically proven MF patients had been admitted to the tertiary referral skin center during a 10-year period and another 150 normal volunteers had been compared with each other for the presence of HTLV-1 infection. Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies against HTLV-1, and positive results were confirmed with western blotting.Results:
Only three MF patients had HTLV-1 infection, whereas two cases of normal subjects had the infection ( P > 0.05). The only three seropositive MF patients were male and from North-Eastern Iran .Conclusion:
This study showed that MF does not correlate with HTLV-1 infection in Iran.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2009
Type:
Article
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