Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
Indian J Dermatol Venereol Leprol
;
2009 Nov-Dec; 75(6): 579-582
Article
in English
| IMSEAR
| ID: sea-140466
ABSTRACT
Background:
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.Aim:
To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.Methods:
Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.Results:
Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.Conclusion:
This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2009
Type:
Article
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