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Ichthyosiform mycosis fungoides with alopecia and atypical membranous nephropathy.
Indian J Dermatol Venereol Leprol ; 2011 Mar-Apr; 77(2): 180-183
Article in English | IMSEAR | ID: sea-140804
ABSTRACT
We describe here a rare case of variant of mycosis fungoides (MF) ichthyosiform MF with alopecia and atypical membranous nephropathy. The diagnosis was made based on the following

findings:

generalized ichthyosis-like eruption, alopecia, enlarged superficial lymph nodes, proteinuria, and hematuria, the histological features of the skin biopsy from both ichthyotic and alopecic lesions with immunohistochemical staining, and the renal biopsy examination with immunofluorescence. The histological examination of ichthyotic and alopecic lesions displayed a predominant infiltration of atypical lymphocytes in the upper dermis with the characteristics of epidermotropism and folliculotropism. Immunohistochemical studies demonstrated that most infiltrated atypical lymphocytes were CD3, CD4, and CD45RO positive, whereas negative for CD5, CD7, CD20, CD30, and CD56. A renal biopsy examination revealed atypical membranous nephropathy with deposition of immunoglobulin G (IgG), IgM, IgA, C1q, and C3. In this case atypical membranous nephropathy was involved, which is very uncommon and has never been presented in the literature to date. Although ichthyosiform MF usually features a relatively favorable course, diffuse alopecia and the renal involvement in this case might indicate aggressive disease and poor prognosis.

Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: Indian J Dermatol Venereol Leprol Year: 2011 Type: Article
Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: Indian J Dermatol Venereol Leprol Year: 2011 Type: Article