Comparative analysis of protein structure of common Hb Q variants.
Indian J Pathol Microbiol
;
2010 Oct-Dec; 53(4): 696-698
Article
in English
| IMSEAR
| ID: sea-141789
ABSTRACT
Context Hemoglobin (Hb) Q variant is a group of hemoglobinopathies prevalent in south, south-east and western Asia. The primary structure of all of these molecules is well known. However, very little is known about the secondary and tertiary structures of these molecules. Therefore, a study of their secondary and tertiary structures is needed. Aim:
The study was aimed at investigating the secondary and tertiary structures of common Hb Q variants using bioinformatics tool. Settings andDesign:
The secondary and tertiary structures of common Hb Q variants were evaluated using NNPREDICT server and CPHmodels 2.0 server, respectively. Materials andMethods:
Amino acid sequence of alpha globin chain was searched using ExPASY and was used for further mutation to Hb Q variants. The derived sequences were further analyzed using NNPREDICT server and CPHmodels 2.0 server to calculate their secondary and tertiary structures, respectively. These were then compared and any differences noted.Results:
It was observed that there is no difference between the predicted secondary structures of normal alpha globin and Hb Q-India. Hb Q-Iran carries an extra helix while Hb Q-Thailand carries two extra helices. The results of tertiary structure prediction also support these findings.Conclusions:
Differences in secondary and tertiary structure of various Hb Q variants have been observed in the present study. The study provides valuable data for better understanding of these uncommon hemoglobinopathies.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS