A cytohistological study of Ki-67 expression in ovarian tumors.
Indian J Pathol Microbiol
;
2011 Jan-Mar 54(1): 21-24
Article
in English
| IMSEAR
| ID: sea-141885
ABSTRACT
Background and Objective:
The study was conducted to evaluate the diagnostic accuracy of imprint cytology in ovarian neoplasms, and to investigate the biological significance of Ki-67 antigen expression in benign and malignant ovarian tumors and correlate it with histological type, grade, and stage of malignant tumor. Materials andMethods:
A total of 50 cases including 25 prospective and 25 retrospective cases were studied. Imprint cytology was performed on 25 ovarian tumors and compared with histopathological diagnosis. Ki-67 immunohistochemistry was performed on all 50 cases.Results:
On immunohistochemistry, benign tumors had a mean Ki-67 index of 3.2 ± 3.7 while malignant tumors had a mean Ki-67 index of 33.1 ± 16.7, the difference being statistically significant. Significant correlation was observed between the Ki-67 index and stage of the tumor; however, there was no correlation between the grade of differentiation and histological type of tumor with the Ki-67 index.Conclusions:
In the present study, the Ki-67 index was higher in advanced stage tumors; hence a higher Ki-67 index points toward the aggressive behavior and poorer clinical outcomes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ovarian Neoplasms
/
Severity of Illness Index
/
Female
/
Humans
/
Immunohistochemistry
/
Biomarkers
/
Ki-67 Antigen
/
Adult
/
Gene Expression Profiling
/
Microscopy
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2011
Type:
Article
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