Detection of HIV drug resistance mutations in pregnant women receiving single dose Nevirapine in south India.
Indian J Pathol Microbiol
;
2011 Apr-Jun 54(2): 359-361
Article
in English
| IMSEAR
| ID: sea-141987
ABSTRACT
Background:
Single dose of Nevirapine to prevent mother to child transmission of HIV is the commonest preventive regimen in resource-limited countries.Objectives:
The objective of this study was to detect drug-resistant virus after single dose of Nevirapine (sdNVP) provided to delivering HIV seropositive (HIV+ve) women and to evaluate the time taken for its decay.Results:
Of the 36 consenting HIV+ve pregnant women enrolled into the study, the mean hemoglobin and total lymphocyte counts were 10.8 g/dl and 1843 cells/mm 3 , respectively. Mean CD4 counts in 64% of women was 363 cells/mm 3 and mean viral load for 16/36 women was 28,143 copies/ml of plasma. Nevirapine-resistance mutations were detected in 28% of women at delivery; using OLA (Oligonucleotide Ligation Assay). K103N mutations were seen in 19.4% of women while the Y181C mutation was seen in 5%. Both the mutations were detected in 2.7% of women. Sequential blood samples collected at delivery, 7-10 days, 6 weeks, 4 months, 6 months and one year postpartum showed that 81% of K103N mutations and 66.7% of Y181C mutations were detected at 6 weeks postpartum . Wild-type virus had replaced the mutants by one year postpartum in all women except one.Conclusion:
These observations are relevant for future treatment with antiretroviral therapy in these women for their HIV disease.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications, Infectious
/
Female
/
Humans
/
Pregnancy
/
HIV Infections
/
HIV
/
Infectious Disease Transmission, Vertical
/
Anti-HIV Agents
/
Adult
/
Nevirapine
Type of study:
Diagnostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2011
Type:
Article
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