Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study.
Indian J Pathol Microbiol
;
2011 Jul-Sept 54(3): 526-531
Article
in English
| IMSEAR
| ID: sea-142036
ABSTRACT
Introduction:
Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix. Materials andMethods:
In our study, we used immunohistochemical methods for the evaluation of COX-2, MMP-2 and MMP-9 expression in tissue samples of 30 primary and 10 recurrent skin BCC cases.Results:
Immunohistochemical COX-2 expression was significantly higher in the infiltrating pattern of BCC compared with the nodular (P = 0.005) and superficial (P = 0.041) subtypes in the primary BCC group. There was not a significant difference between nodular and superficial BCCs for COX-2 expression. In addition, COX-2 expression was significantly higher in the recurrent BCC group than in the primary BCC group (P = 0.030). There was no statistically significant difference between the histological subtypes of primary BCCs and between primary and recurrent BCCs for MMP-2 and MMP-9 expressions.Conclusions:
Our data confirm previous findings that COX-2 and MMP-9 expressions are increased in BCC. Our results revealed an elevated COX-2 expression in recurrent BCCs. We suggest that COX-2 inhibition might have beneficial effects in BCCs, especially for the tumors with a higher level of COX-2 expression or aggressive phenotype.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Recurrence
/
Skin
/
Skin Neoplasms
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Carcinoma, Basal Cell
/
Pilot Projects
Limits:
Aged80
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2011
Type:
Article
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