Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype.
Indian J Pathol Microbiol
;
2011 Jul-Sept 54(3): 591-593
Article
in English
| IMSEAR
| ID: sea-142052
ABSTRACT
Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenotype
/
Recurrence
/
Repressor Proteins
/
Vincristine
/
Superior Vena Cava Syndrome
/
Humans
/
Male
/
Prednisone
/
Immunohistochemistry
/
B-Lymphocytes
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2011
Type:
Article
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