Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.
Indian J Pathol Microbiol
;
2011 Jul-Sept 54(3): 599-602
Article
in English
| IMSEAR
| ID: sea-142055
ABSTRACT
Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Leukocytes, Mononuclear
/
Leukemia, Lymphoid
/
Child
/
Adolescent
/
Leukocyte Common Antigens
/
Receptor Protein-Tyrosine Kinases
/
Lymphoma, Large-Cell, Anaplastic
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2011
Type:
Article
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