Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study.
Indian J Pathol Microbiol
;
2012 Jan-Mar 55(1): 28-32
Article
in English
| IMSEAR
| ID: sea-142171
ABSTRACT
Context The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides in a more uniform manner required relook at our eight-year data. Aims:
To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN) and also to seek any significant differences in renal histology of C-ANCA-positive, P-ANCA-positive, and ANCA-negative patients. Materials andMethods:
A detailed analysis of the histopathologic features of renal biopsies of 48 patients in whom a diagnosis of pauci-immune glomerulonephritis was concluded on renal biopsy and who presented clinically as rapidly progressive renal failure was done. Statistical Analysis Used One-way ANOVA and Pearson Chi square tests.Results:
Compared with ANCA +ve patients, the ANCA -ve patients were much younger (46.85 ± 16.12 years vs 34.28±15.94 years). No significant differences were found between renal lesions of C-ANCA, P-ANCA, and ANCA-negative patients, except for diffuse tubular atrophy which was more severe and more frequently present with P-ANCA positivity (P value=0.013).Conclusions:
Pauci-immune RPGN (irrespective of ANCA status) is a relatively rare disorder in patients who are undergoing the renal biopsy at our institute, constituting 2% of all renal biopsies submitted. It is mandatory to have ANCA serology status during reporting of a kidney biopsy showing pauci-immune crescentic or necrotizing glomerulonephritis. Also, if a uniform reporting strategy is followed throughout the country, the studies from this vast country will be comparable.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Biopsy
/
Aged
/
Female
/
Humans
/
Male
/
Immunohistochemistry
/
Child
/
Child, Preschool
/
Retrospective Studies
/
Adolescent
Type of study:
Observational study
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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