Molecular phenotypes of ductal carcinoma-in-situ and invasive ductal carcinoma: A comparative study.
Indian J Pathol Microbiol
;
2012 Jan-Mar 55(1): 43-46
Article
in English
| IMSEAR
| ID: sea-142174
ABSTRACT
Aims and Objectives:
This study was aimed at analyzing the prevalence of molecular phenotypes in invasive ductal carcinoma (IDC) and coexisting ductal carcinoma-in-situ (DCIS) and to correlate with clinicopathological features. Materials andMethods:
In this study, 75 cases of IDC with coexisting DCIS were included. Molecular phenotype was determined using expression of estrogen receptor, progesterone receptor, HER2/neu, and cytokeratin 5/6. Statistical analysis was performed for correlation between molecular phenotypes and clinicopathologic parameters.Results:
Of the 75 cases, the invasive component in all cases was IDC-not otherwise specified. About one-third of our patients were post-menopausal. The most common molecular phenotype was luminal A (45.3%) followed by HER2-expressing type (24%). In all cases, the molecular phenotype was identical in DCIS and the invasive component. HER2-expressing tumors were found to be larger in size with frequent nodal involvement. On statistical analysis, tumor size and grade were found to correlate with the molecular phenotype.Conclusion:
In conclusion, the molecular phenotype in DCIS correlates well with that of coexisting IDC, suggesting that DCIS is a precursor lesion in these tumors. This correlation of molecular phenotype can be utilized in prediction of phenotype of the invasive component in a case with in-situ carcinoma.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged, 80 and over
/
Aged
/
Humans
/
Immunohistochemistry
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Biomarkers, Tumor
/
Retrospective Studies
/
Carcinoma, Intraductal, Noninfiltrating
/
Receptor, ErbB-2
Type of study:
Observational study
/
Risk factors
Limits:
Aged80
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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