Clinicopathological spectrum of 19 adenosarcomas of female genital tract, including uncommon clinical associations and immunohistochemical profile, reviewed at a single institution.
Indian J Pathol Microbiol
;
2012 Jul-Sept 55(3): 326-332
Article
in English
| IMSEAR
| ID: sea-142261
ABSTRACT
Background:
Adenosarcomas of the female genital tract have been rarely documented as case series from our continent. Materials andMethods:
Over a seven-year period, 19 adenosarcomas were critically reviewed.Results:
Nineteen tumors occurred in the age range of 21-65 years (mean 43), in the endometrium (8), endometrium and cervix (4), cervix (4), and ovary (3). Four cases displayed coexisting leiomyomas; two, adenomyosis; two on background endometriosis; and one in post-treated cervix carcinoma. Histopathologically, the tumors were low grade (10; 52.6%) and high grade (9; 47.3%), the latter with sarcomatous overgrowth (SO) (7/9 cases). Dedifferentiation (8, 42.1%) and conspicuous decidualization (2) were noted. Immunohistochemically, the tumors focally expressed CD10 (4/6), smooth muscle actin (SMA) (3/8), desmin (8/11); diffuse vimentin (7/7), and estrogen receptor/progesterone receptor (ER/PR) (2/4). Ki-67 (6 cases) varied 5-20%. Seventeen patients underwent surgery and four received adjuvant treatment (3/4 high-grade tumors). Five tumors recurred (4 high-grade tumors with SO) and one metastasized. Among 11 patients, five were alive with disease (AWD) (mean 29.4 months) and six, free of disease (FOD) (mean 15 months), the latter mostly with low-grade type tumors (83.3% cases).Conclusions:
Diverse clinicopathological spectrum was noted within adenosarcomas. Low-grade tumors were less aggressive than high-grade ones, with SO. Immunohistochemically, lower CD10 and ER/PR positivity was noted in high-grade tumors. Surgery formed the mainstay of treatment. Adjuvant treatment was offered in high-grade subtypes, including in tumors with SO.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged
/
Female
/
Humans
/
Immunohistochemistry
/
Adenosarcoma
/
Adult
/
Young Adult
/
Genital Neoplasms, Female
/
Histocytochemistry
/
Microscopy
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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