The utility of p16 INK4a and Ki-67 to identify high-grade squamous intraepithelial lesion in adolescents and young women.
Indian J Pathol Microbiol
;
2012 Jul-Sept 55(3): 339-342
Article
in English
| IMSEAR
| ID: sea-142263
ABSTRACT
Background:
The repair of the immature squamous epithelium following HPV infection may mimic HSIL in adolescent women.Aim:
to study the utility of p16 INK4a and Ki-67 in diagnosis of cervical squamous lesions in adolescents and young adults. Materials andMethods:
In a cross-sectional study, the evaluation of p16 INK4a and Ki-67 immunohistochemistry was performed on 72 cervical biopsies of adolescents and young adults women diagnosed as negative for malignancy and intraepithelial lesion (NML) (n = 18) or positive for low grade (LSIL) (n = 31) and high grade (HSIL) (n = 23) squamous intraepithelial lesions in two references services in Fortaleza-Brazil. Data was evaluated using Fisher's test and Kappa index.Results:
p16 INK4a was positive in 81% of HSIL, 19% of LSIL and in no NML (P < 0.0001). Ki-67 was positive in 74%, 32% and 5.5% of HSIL, LSIL and NML, respectively. p16 INK4a and Ki-67 in the diagnosis of HSIL showed high sensitivity and negative predictive value. Kappa index was very good for p16 INK4a (k = 0.72).Conclusions:
In adolescents and young adults p16 INK4a alone or with Ki-67 represents important tool to reduce mistaken diagnosis of HSIL and to avoid overtreatment.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Biopsy
/
Brazil
/
Female
/
Humans
/
Immunohistochemistry
/
Uterine Cervical Dysplasia
/
Cervix Uteri
/
Cross-Sectional Studies
/
Adolescent
/
Neoplasms, Squamous Cell
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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