Vincristine induced neurotoxicity in cancer patients.
Indian J Pediatr
;
2010 Jan; 77(1): 97-100
Article
in English
| IMSEAR
| ID: sea-142481
ABSTRACT
Ten out of 20 children, treated with usual doses of vincristine for various types of childhood cancers, developed neurotoxicity during treatment. Peripheral neurotoxicity (mixed motor-sensory 4/10, pure motor 3/10, pure sensory 3/10) was seen in the form of weakness of lower limbs, areflexia, neuropathic pain, or sensory loss. Autonomic neuropathy presented as constipation and urinary retention in 2 children, while 2 children developed encephalopathy in form of seizures, confusion, aphasia, and transient blindness. In children with severe neuropathy, vincristine administration was withheld/dose reduced till clinical improvement started, which took about 2-3 weeks time. Nerve conduction velocity showed motor-sensory axonal polyneuropathy. Electrophysiological abnormalities were found to persist even six months after clinical recovery in children with neurotoxicity. We found a relatively higher incidence of vincristine induced neuropathy in Indian children, which was probably due to coexistence of severe malnutrition in them.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vincristine
/
Female
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Peripheral Nervous System Diseases
/
Malnutrition
/
India
/
Neoplasms
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
2010
Type:
Article
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