Chromosome 12;15 rearrangements in patients with recurrent miscarriage.
Indian J Hum Genet
;
2006 Sept; 12(3): 133-139
Article
in English
| IMSEAR
| ID: sea-143314
ABSTRACT
Background:
An abnormal karyotype in either partner, especially featuring a translocation and/or inversion is considered to be a cause of recurrent miscarriages. It is generally assumed that recurrent miscarriage might be due to recurrent chromosomal abnormalities in the fetus due to a balanced aberration in one of the parents being inherited by the offspring in an unbalanced form.Aim:
Evaluation of chromosomal rearrangements in couples with recurrent miscarriages. Materials andMethods:
Peripheral blood was collected and lymphocyte cultures were set up. Slides prepared from the cell suspension were stained and screened for metaphases followed by karyotyping.Result:
Balanced translocation was observed in the male partner in one case and in the female partners in the three other cases.Conclusion:
Couples with recurrent miscarriage should be investigated for chromosomal rearrangements, thus helping in genetic counseling and providing the options for future pregnancies.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Hum Genet
Year:
2006
Type:
Article
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