Prevalence and risk factors for colonisation with extended spectrum β-lactamase producing enterobacteriacae vis-à-vis usage of antimicrobials.
Indian J Med Microbiol
;
2010 Jul-Sept; 28(3): 217-220
Article
in English
| IMSEAR
| ID: sea-143701
ABSTRACT
Purpose:
A point prevalence study was carried out in a teaching hospital in Assam to determine the prevalence, sensitivity profile and risk factors for acquisition of extended spectrum β-lactamase (ESBL) producing enterobacteriacae vis-ΰ-vis amount and pattern of antibiotic use. Materials andMethods:
ESBL was detected by double disc synergy method. Defined daily dose and bed-days were calculated.Result:
Colonisation rate of ESBL producing enterobacteriacae ranged from 14% (n=73) in medicine to the highest 41% (n=29) in orthopaedic with an intermediate 23% (n=80) in surgery. Presence of ESBL was found to be strongly associated with resistance to specific classes of antimicrobials. Exposure to cefotaxime and gentamicin, and surgery were risk factors for acquiring ESBL producing enterobacteriacae. Non-ESBL producing community isolates were found to be considerably more sensitive to different antibiotics with no resistance detected to trimethoprim, co-trimoxazole, ciprofloxacin and aminoglycosides.Conclusion:
The study confirms the role of certain 'high risk' antimicrobials in acquisition of ESBL producing Enterobacteriaceae and shows that periodic cohort studies could be an effective strategy in surveillance of antimicrobial resistance in hospitals of resource poor countries to inform antibiotic policy and treatment guidelines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Practice guideline
/
Observational study
/
Prevalence study
/
Risk factors
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2010
Type:
Article
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