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BinaxNOW® - An immunochromatographic test for the diagnosis of human influenza viruses: Comparison with viral culture and polymerase chain reaction.
Indian J Med Microbiol ; 2011 Jan-Mar; 29(1): 19-21
Article in English | IMSEAR | ID: sea-143769
ABSTRACT

Purpose:

A rapid test for influenza viruses (Binax NOW® ) was evaluated. Materials and

Methods:

In season-1, 35 respiratory samples were tested retrospectively; in season-2, 45 samples were tested prospectively [gold-standard viral culture in season-1, culture+ reverse transcriptase-polymerase chain reaction (RT-PCR) in season-2].

Results:

Sensitivity for Binax for influenza A was 59.3 and 0% in season-1 and -2, respectively. Sensitivity was low for influenza B (33.3% in season-1, 26.1% in season-2). Samples having low viral load were more likely to have a negative Binax test. Specificity of Binax was high (100 and 94.7% with influenza A and B, respectively).

Conclusion:

Sensitivity information provided in the kit insert does not always reflect post licensure performance in clinical settings.
Subject(s)

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Orthomyxoviridae / Reagent Kits, Diagnostic / Time Factors / Virology / Virus Cultivation / Humans / Immunoassay / Polymerase Chain Reaction / Sensitivity and Specificity / Clinical Laboratory Techniques Type of study: Diagnostic study Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2011 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Orthomyxoviridae / Reagent Kits, Diagnostic / Time Factors / Virology / Virus Cultivation / Humans / Immunoassay / Polymerase Chain Reaction / Sensitivity and Specificity / Clinical Laboratory Techniques Type of study: Diagnostic study Language: English Journal: Indian J Med Microbiol Journal subject: Microbiology Year: 2011 Type: Article