Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: A single institutional experience.
Indian J Med Microbiol
;
2011 Oct-Dec; 29(4): 414-417
Article
in English
| IMSEAR
| ID: sea-143867
ABSTRACT
Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged
/
Female
/
Humans
/
Male
/
Complement System Proteins
/
Cytotoxicity Tests, Immunologic
/
Histocompatibility Testing
/
Child
/
Child, Preschool
/
Retrospective Studies
Type of study:
Observational study
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2011
Type:
Article
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