Colistin against colistin-only-susceptible Acinetobacter baumannii-related infections: Monotherapy or combination therapy.
Indian J Med Microbiol
;
2012 Oct-Dec; 30(4): 448-452
Article
in English
| IMSEAR
| ID: sea-144008
ABSTRACT
Purpose:
To evaluate the outcomes of the patients who were infected with colistin-only-susceptible (COS) Acinetobacter baumannii and treated with either colistin monotherapy or colistin combined therapy. Materials andMethods:
This retrospective case-control study was conducted in the training and research hospital with an 800 beds between August 2008 and December 2011. The patients, who were infected with COS A. baumannii and received either colistin monotherapy or colistin combined therapy, were included into the study.Results:
In total, 51 patients fulfilling study criteria were evaluated. Colistin monotherapy was found effective as much as colistin combined therapy in terms of clinical and microbiological responses in patients with ventilator associated pneumonia (VAP) and also in patients with blood stream infections.Conclusion:
Although there is no randomised controlled study yet, colistin monotherapy and colistin combined therapy are likely to achieve similar treatment responses rates. Heteroresistant strains can emerge in patients who receive colistin monotherapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Patients
/
Humans
/
Gram-Negative Bacterial Infections
/
Colistin
/
Drug Resistance, Bacterial
/
Acinetobacter baumannii
/
Drug Therapy, Combination
/
Pneumonia, Ventilator-Associated
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
/
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2012
Type:
Article
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