Granulocyte transfusion in children.

Raj, Revathi; Kamath, Shrishu R; Ranjit, Suchitra; Shankar, Nirmal; Lakshmanan, V

Raj, Revathi; Kamath, Shrishu R; Ranjit, Suchitra; Shankar, Nirmal; Lakshmanan, V.

Indian Pediatr ; 2009 June; 46(6): 516-518

Article in English | IMSEAR | ID: sea-144061

ABSTRACT

ABSTRACT

We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and growth factors in post chemotherapy neutropenic sepsis and is highly effective in children with chronic granulomatous disease and life threatening infections.

Subject(s)

Adolescent; Child; Child, Preschool; Female; Granulocytes; Humans; India/epidemiology; Infant; Leukocyte Transfusion/methods; Leukocyte Transfusion/mortality; Male; Neutropenia/etiology; Neutropenia/mortality; Neutropenia/therapy; Retrospective Studies; Sepsis/blood; Sepsis/complications; Sepsis/mortality; Treatment Outcome

Granulocyte transfusion; Neutropenia; Sepsis

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Humans / Male / Child / Child, Preschool / Retrospective Studies / Adolescent / Treatment Outcome / Leukocyte Transfusion / Sepsis Type of study: Observational study Country/Region as subject: Asia Language: English Journal: Indian Pediatr Year: 2009 Type: Article

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