Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: A case-control study.
Indian Pediatr
;
2009 Aug; 46(8): 675-680
Article
in English
| IMSEAR
| ID: sea-144149
ABSTRACT
Objectives:
To measure the cord blood and maternal serum levels of folic acid, vitamin B12, zinc, copper, selenium and lead in infants born with neural tube defect (NTD), and to examine a possible relationship between the nutriture of these micronutrients and occurrence of neural tube defect.Design:
Case-control study.Methods:
Maternal serum and cord blood samples were obtained at delivery from 70 healthy mothers and 74 mothers who had a newborn with NTD.Results:
The mean (± SD) maternal serum zinc level in the NTD group was significantly lower than that of the control group (835.6 µg/L ±333.8 µg/L vs. 1035.7 µg/L ± 299.8 µg/L, P=0.004, respectively). The mean maternal and cord serum copper levels in the NTD group were significantly higher when compared to the control group (2831.1 µg/L ± 1017 µg/L vs. 2402 µg/L ± 744.2 µg/L; P=0.03; and 789.8 µg/L vs 517.2 µg/L, P<0.001, respectively). There was a negative correlation between the cord levels of folic acid and copper in the NTD group with the respective maternal serum levels (r=-0.289; P=0.018).Conclusions:
High maternal serum levels of copper and lower level of zinc during pregnancy associated with NTD in newborn.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications
/
Zinc
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
/
Case-Control Studies
/
Micronutrients
/
Copper
/
Prenatal Nutritional Physiological Phenomena
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
Indian Pediatr
Year:
2009
Type:
Article
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