p 53 codon 72 polymorphism in stomach and colorectal adenocarcinomas in Iranian patients.
Indian J Cancer
;
2010 Jan-Mar; 47(1): 31-34
Article
in English
| IMSEAR
| ID: sea-144290
ABSTRACT
Background:
The association of a functional single nucleotide polymorphism at codon 72 of the p53 gene (Arg72Pro) with malignancy is a subject of controversy. We analyzed this polymorphism in 224 patients with gastrointestinal cancers (92 with stomach cancer and 132 with colorectal cancer) and in 163 healthy controls. Material andMethods:
DNA was extracted from peripheral blood mononuclear cells and amplified with an allele-specific polymerase chain reaction.Results:
There was no significant association between p53 alleles and gastrointestinal cancers. The frequency of the Arg allele was 59.7, 58.8, and 59.2% in the stomach cancer patients, colorectal cancer patients, and controls, respectively. Frequencies of the Pro allele were 40.3% in patients with stomach cancer, 41.2% in patients with colorectal cancer, and 40.8% in controls. Likewise, genotype frequencies did not differ significantly between the two patient groups and controls. There were no differences in genotype or allele frequencies by gender, age, or histological grade.Conclusions:
The data do not support the association of the p53 codon 72 polymorphism with stomach or colorectal cancers in Iranian patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Neoplasms
/
Female
/
Humans
/
Male
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Polymerase Chain Reaction
/
Tumor Suppressor Protein p53
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Cancer
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS